Clinical Inquiries

Does chocolate have cardiovascular benefits?

Author and Disclosure Information

 

References

EVIDENCE-BASED ANSWER

YES, EATING CHOCOLATE REDUCES BLOOD PRESSURE in the short term (strength of recommendation [SOR]: B, a meta-analysis and individual randomized controlled trials [RCTs]). No studies, however, have evaluated the long-term cardiovascular effects of chocolate.

Chocolate contains high levels of flavonol; a diet rich in flavonoids is associated with reduced death rates from coronary heart disease (SOR: B, prospective observational studies, which didn’t evaluate chocolate intake specifically).

Evidence summary

A meta-analysis and 3 subsequent single-blinded RCTs showed a short-term decrease in blood pressure with daily consumption of chocolate. The meta-analysis was comprised of 5 randomized controlled parallel-group or crossover studies with a total of 173 adult patients, both normotensive and hypertensive. Patients ate dark chocolate, high-flavonol milk chocolate, white chocolate, or chocolate without flavonol daily for 14 to 15 days. Four studies used 100 to 105 g (approximately 3 oz) of chocolate (480 calories, 500 mg polyphenols, including flavonol), and 1 used 46 g (240 calories, 213 mg flavonol). Investigators didn’t report the percent of cocoa in the chocolate used.1

Dark chocolate and high-flavonol milk chocolate significantly reduced both systolic blood pressure (–4.7 mm Hg; 95% confidence interval [CI], –7.6 to –1.8 mm Hg; P=.002) and diastolic pressure (–2.8 mm Hg; 95% CI, –4.8 to –0.8 mm Hg; P=.006). The study using the 46-g dose found no difference in blood pressure. Removing this outlier from the analysis didn’t alter the mean blood pressure changes.1

From hypertensive to prehypertensive with help from chocolate
An RCT evaluated 44 adults, 56 to 73 years of age, with untreated upper-range prehypertension or stage 1 hypertension without concomitant risk factors. Subjects consumed either 6.3 g (30 kcal) per day of dark chocolate (50% cocoa) or polyphenol-free (hence flavonol-free) white chocolate for 18 weeks.2 Dark chocolate significantly reduced systolic and diastolic blood pressures (systolic: –2.9±1.6 mm Hg; P<.001; diastolic: –1.9±1.0 mm Hg; P<.001) compared with white chocolate.

Four patients who ate dark chocolate (18%) were reclassified from “hypertensive” to “prehypertensive.” None achieved lower-range prehypertension (<130/85) or optimal blood pressure, however. To place this finding in clinical perspective, the authors cite data from the Framingham Heart Study indicating that a 3-mm Hg reduction in systolic blood pressure should reduce the relative risk of stroke mortality by 8%, of mortality from coronary artery disease by 5%, and of all-cause mortality by 4%.2

Pages

Evidence-based answers from the Family Physicians Inquiries Network

Recommended Reading

Psoriasis Elevates Patients' Risk for Cardiovascular Events
MDedge Family Medicine
Ankle Brachial Index May Affect CHD Risk Status
MDedge Family Medicine
New Screening Tool Improves AAA Detection
MDedge Family Medicine
Follow-Up Lowers Heart Failure Readmissions
MDedge Family Medicine
Subclinical Atherosclerosis Seen in Middle-Aged Marathoners
MDedge Family Medicine
CAD Events Less Likely With Normal Vitamin D
MDedge Family Medicine
Dabigatran Bests Warfarin in Low-Risk A Fib Patients
MDedge Family Medicine
Calcium Score Improves CHD Risk Prediction
MDedge Family Medicine
Optimize your use of stress tests: A Q&A guide
MDedge Family Medicine
Does hypercoagulopathy testing benefit patients with DVT?
MDedge Family Medicine